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Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor

Received: 18 June 2022     Accepted: 20 July 2022     Published: 29 July 2022
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Abstract

Preterm birth is the biggest cause of mortality in children under 5 years old in the world. The main causes of preterm birth are inflammation and intrauterine infection. Vitamin D plays a role in preventing preterm birth by reducing the oxidative stress of tissues that causes an inflammatory reaction. The purpose of this study is to determine that low maternal Vitamin D serum level as a risk factor for preterm delivery. This study is an analytic study with case control design with 54 samples, and divided into two groups, 27 preterm delivery samples as a case group and 27 preterm pregnancy samples as a control group. This research was conducted at the Obstetric and Gynecology Outpatient Clinic and the delivery room at Sanglah Hospital Denpasar during December 2018 to April 2019. The results of this study found a statistically significant difference (p = 0.028) between the case and control groups. Low vitamin D levels are a risk factor for preterm labor by 3.45 times compared with patients with high vitamin D levels (OR = 3.45, 95% CI = 1.12-10.67, p = 0.028). The conclusion of this study was that low maternal 25(OH)D (Vitamin D) serum levels is a risk factor for preterm deliveries.

Published in Journal of Gynecology and Obstetrics (Volume 10, Issue 4)
DOI 10.11648/j.jgo.20221004.14
Page(s) 186-189
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Preterm Deliveries, Vitamin D, Risk Factor

References
[1] Ekkehard S. The prevention, diagnosis, and treatment of premature labour. Dtsch Arzetbl Int. 2013; 110 (13): 227-36.
[2] Blencowe, H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Garcia CV, Rohde S, Say L, Lawn JN. National, regional and worldwide estimates of preterm birth rates in the year 2010 with time trends for selected countries since 1990: a Systematic Analysis and Implication. Estimates for World Health Organization 2012. The Lancet 2012; 379: 2162-72.
[3] Sentana O, Kardana M. Faktor yang terkait dengan kelahiran bayi kurang bulan di RSUP Sanglah Denpasar. Medicina 2017; 48 (2): 83-7.
[4] Lockwood CJ. Testing for Risk of Preterm Delivery. Clin Lab Med 2003; 23: 345-60.
[5] Holmes S, Abbassi B, Su C, Singh M, Cunningham RL. Oxydative Stress and Inflammation are Alleviated by Products from Grapes. Oxid Med Cell Longev 2016; 16: 1-12.
[6] Wei R, Christakos S. Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D. Nutrients 2015; 7: 8251–60.
[7] Beilfuss J, Berg V, Sneve M, Jorde, R, Kamycheva E. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alphaand insulin resistance in overweight and obese subjects. Cytokine 2012; 60: 870–4.
[8] Baker AM, Haeri S, Camargo CA, Stuebe AM, Boggess KA. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev 2012; 28 (2): 164–8.
[9] Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’Beirne M, Rabi DM. Association between maternal serum 25-Hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ 2012; 346: 1169.
[10] Rodriguez A, Garcia-Esteban R, Basterretxea M, Lertxundi A, Rodruguez-Bernal C, Iniguez C, Rodriguez-Dehli C, Tardon A, Espada M, Sunyer J, Morales E. Associations of maternal circulating 25-Hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG 2014; 1: 1-8.
[11] Qin LL, Lu FG, Yang SH, Xu HL, Luo BA. Does maternal vitamin D deficiency increase the risk of preterm birth: A Meta-Analysis of Observational Studies. Nutrients 2016; 8: 301.
[12] Rosenfeld T, Salem H, Altarescu G, Grisaru Granovsky, S, Tevet A, Birk R. Maternal–fetal vitamin D receptor polymorphisms significantly associated with reterm birth. Archives of Gynecology and Obstetrics 2017; 296 (2): 215-22.
[13] Nair R, Maseeh A. Vitamin D: The “Sunshine” Vitamin. J Pharmacol Pharmacother 2012; 3 (2): 118.
[14] Correia A, Socorro-Azevedo M, Gondim F, Bandeira F. Ethnic aspects of vitamin D deficiency. Arq Bras Endocrinol Metab 2014; 58 (5): 540-4.
[15] Yeum KJ, Song BC, Joo NS. Impact of geographic location on vitamin D status and bone mineral Density. Int. J. Environ. Res. Public Health 2016; 13 (2): 184.
[16] Marta BS, Jaroslaw K. Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland. Int J Occup Med Environ Health 2017; 30 (6): 933–41.
[17] McDonnell SL, Baggerly KA, Baggerly CA, Aliano JL, French CB, et al. Maternal 25 (OH)D Concentrations 40 ng/mL Associated with 60% Lower Preterm Birth Risk Among General Obstetrical Patients at an Urban Medical Center. PLoS ONE 2017; 12 (7): e0180483.
[18] Zhou SS, Tao YH, Huang K, Zhu BB, Tao FB. Vitamin D and risk of preterm birth: Up-To-Date Meta-Analysis of Randomized Controlled Trials and Observational Studies J. Obstet. Gynaecol. Res 2017; 43 (2): 247-56.
[19] Singh J, Hariharan C, Bhaumik D. Role of vitamin D in reducing the risk of preterm labour. Int J Reprod Contracept Obstet Gynecol 2015; 4 (1): 86-93.
[20] Bodnar L, Platt R, Hyagriv S. Early pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol 2015; 125 (2): 439–47.
[21] Dovnik A, Mujezivonic F. The association of vitamin D levels with common pregnancy complications. Nutrients 2018; 10: 867-80.
[22] Elhusseini H, Elkafas H, Abdelaziz M. Diet-induced vitamin D deficiency triggers inflammation and DNA damage profile in murine myometrium. International Journal of Women’s Health 2018; 10: 503–14.
[23] Holvik K, Meyer HE, Haug E, Brunvand L. Prevalence and predictors of vitamin D deficiency in five immigrant groups living in Oslo, Norway: the Oslo Immigrant Health Study. Eur J Clin Nutr 2005; 59: 57–63.
[24] Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, Fuleihan G, Josse RG, Lips P, Morales Torres J. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009; 20 (11): 1907-20.
[25] Nimitphong H, Holick FM. Vitamin D status and sun exposure in Southeast Asia. Dermato-endocrinology. 2013; 5 (1): 34–7.
Cite This Article
  • APA Style

    David Eriandi Ginting, Anak Agung Gede Putra Wiradnyana, Ketut Suwiyoga. (2022). Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor. Journal of Gynecology and Obstetrics, 10(4), 186-189. https://doi.org/10.11648/j.jgo.20221004.14

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    ACS Style

    David Eriandi Ginting; Anak Agung Gede Putra Wiradnyana; Ketut Suwiyoga. Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor. J. Gynecol. Obstet. 2022, 10(4), 186-189. doi: 10.11648/j.jgo.20221004.14

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    AMA Style

    David Eriandi Ginting, Anak Agung Gede Putra Wiradnyana, Ketut Suwiyoga. Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor. J Gynecol Obstet. 2022;10(4):186-189. doi: 10.11648/j.jgo.20221004.14

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  • @article{10.11648/j.jgo.20221004.14,
      author = {David Eriandi Ginting and Anak Agung Gede Putra Wiradnyana and Ketut Suwiyoga},
      title = {Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {10},
      number = {4},
      pages = {186-189},
      doi = {10.11648/j.jgo.20221004.14},
      url = {https://doi.org/10.11648/j.jgo.20221004.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221004.14},
      abstract = {Preterm birth is the biggest cause of mortality in children under 5 years old in the world. The main causes of preterm birth are inflammation and intrauterine infection. Vitamin D plays a role in preventing preterm birth by reducing the oxidative stress of tissues that causes an inflammatory reaction. The purpose of this study is to determine that low maternal Vitamin D serum level as a risk factor for preterm delivery. This study is an analytic study with case control design with 54 samples, and divided into two groups, 27 preterm delivery samples as a case group and 27 preterm pregnancy samples as a control group. This research was conducted at the Obstetric and Gynecology Outpatient Clinic and the delivery room at Sanglah Hospital Denpasar during December 2018 to April 2019. The results of this study found a statistically significant difference (p = 0.028) between the case and control groups. Low vitamin D levels are a risk factor for preterm labor by 3.45 times compared with patients with high vitamin D levels (OR = 3.45, 95% CI = 1.12-10.67, p = 0.028). The conclusion of this study was that low maternal 25(OH)D (Vitamin D) serum levels is a risk factor for preterm deliveries.},
     year = {2022}
    }
    

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    T1  - Low Maternal 25(OH)D (Vitamin D) Serum Levels as a Risk Factor for Preterm Labor
    AU  - David Eriandi Ginting
    AU  - Anak Agung Gede Putra Wiradnyana
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    JO  - Journal of Gynecology and Obstetrics
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    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20221004.14
    AB  - Preterm birth is the biggest cause of mortality in children under 5 years old in the world. The main causes of preterm birth are inflammation and intrauterine infection. Vitamin D plays a role in preventing preterm birth by reducing the oxidative stress of tissues that causes an inflammatory reaction. The purpose of this study is to determine that low maternal Vitamin D serum level as a risk factor for preterm delivery. This study is an analytic study with case control design with 54 samples, and divided into two groups, 27 preterm delivery samples as a case group and 27 preterm pregnancy samples as a control group. This research was conducted at the Obstetric and Gynecology Outpatient Clinic and the delivery room at Sanglah Hospital Denpasar during December 2018 to April 2019. The results of this study found a statistically significant difference (p = 0.028) between the case and control groups. Low vitamin D levels are a risk factor for preterm labor by 3.45 times compared with patients with high vitamin D levels (OR = 3.45, 95% CI = 1.12-10.67, p = 0.028). The conclusion of this study was that low maternal 25(OH)D (Vitamin D) serum levels is a risk factor for preterm deliveries.
    VL  - 10
    IS  - 4
    ER  - 

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Author Information
  • Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University, Sanglah Hospital, Denpasar, Indonesia

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